Amagqabantshintshi: Uvavanyo luvavanye ii-neurochemicals ezininzi kunye neeprotein ezibandakanyekayo kukusetyenziswa kweziyobisi. Uphononongo lufumene utshintsho olufanayo oluboniswa kukuziphatha okufanayo kwiigundane ngaphezulu kutyiwa kukutya okunamafutha amaninzi.
I-Int J Obes (yeNdlela). I-2012 Dec 11. doi: 10.1038 / ijo.2012.197.
USharma S, UFernandes MF, I-Fulton S.
imvelaphi
I-CRCHUM kunye neZiko loPhando lweSwekile yaseMontreal; ISebe Lezempilo, Icandelo Lezonyango, eUniversité de Montreal, Montreal, Quebec, Canada.
Abstract
Injongo:
Ukuchonga iinkqubo zoncedo kunye neemvakalelo ezishukumisela ukubuyisela ukutya okuthe tye emva kokususwa kokutya okunamafutha aphezulu (HFD) kunye neuroadaptations ezinxibelelene ne-neurochemical kunye neendlela zokuziphatha eziphantsi kokusebenza kwe-dopaminergic.
Iindlela:
Indoda enkulu C57Bl6 iimpuku thinaibekwe kwakhona kwi-HFD (i-58% kcal fat) okanye i-ingredient-ukutya, ukutya okunamafutha asezantsi (LFD; 11% kcal fat) kwiiveki ze-6. Ukuphela kweempuku zerejimeni yokutya bekugcinwa kuhlobo lokutya, okanye i-HFD kunye ne-LFD itshintshwe nge-chow eqhelekileyo (ukurhoxa).
Ukusebenza okusekwe kwimizamo yokuphendula i-sucrose kunye nokutya okunamafutha aphezulu kuye kwalinganiswa kunye namanqanaba e-corticosterone asisiseko kunye noxinzelelo (ukuphakanyiswa kwe-maze). Amanqanaba eprotein ye-tyrosine hydroxylase (TH), i-corticosterone ekhulula i-factor factor 1 receptor (CRF-R1), i-neurotrophic factor (BDNF), iphospho-CREB (pCREB) kunye ne-ΔFosB (i-truncated splice variant of FosB) yavavanywa ku-FosB. , i-nucleus accumbens (NAc) kunye ne-ventral tegmental area (VTA) ngokudlula kwi-Western immunoblotting.
iziphumo:
Iiveki ezintandathu ze-HFD zikhokelela ekufumaneni ubunzima obukhulu bokufumana i-ancronia ye-sucrose, ukuxhalaba okufana nokuziphatha kunye ne-hypothalamic-pituitary-adrenocortical axis (HPA) hypersensitivity yoxinzelelo. Ukurhoxa kwi-HFD kodwa hayi i-LFD-ixhala elinokubakho kunye namanqanaba e-corticosterone asisiseko kunye nenkuthazo ephuculweyo ye-sucrose kunye nemivuzo ephezulu yokutya.
Ukutya okunamafutha aphezulu okungapheliyo kunciphise i-CRF-R1 kunye nokunyusa amanqanaba e-BDNF kunye ne-pCREB kwi-amygdala kwaye kuncitshiswe i-TH kunye inyuse iprotheni ye-ΔFosB kwi-NAc nakwiVTA. Umvuzo ophakamileyo wokutya okunokufikelelwa kwiimpuku ezikhutshiweyo kwi-HFD zihambelana nokunyuka kwamanqanaba eprotein ye-BDNF kwi-NAc kwaye kunciphise ukubonakaliswa kwe-TH kunye ne-pCREB kwi-amygdala.
Isiphelo:
I-Anhedonia, ixhala kunye nobuthathaka koxinzelelo lwenzeka ngexesha le-HFD kwaye inokuba nendima ephambili kumjikelezo ombi oqhuba ukondliwa kwamafutha aphezulu kunye nophuhliso lokutyeba kakhulu. Ukususwa kwe-HFD kuphucula iimpendulo zoxinzelelo kunye nokunyusa umngcipheko wokutya okunokuthenjwa ngokwandisa indlela yokuziphatha ekhuthazwayo. Iinguqu ezihlala zihleli kwi-dopamine kunye neempawu ezinxulumene neplastikhi kumjikelezo womvuzo zinokukhuthaza imo yeemvakalelo ezingalunganga, ukugqithisa ukutya kunye nokuvuselela ukutya.
Ijenali yeLizwe ye-Obesity mapema ukupapashwa kwi-intanethi, 11 ngoDisemba 2012; doi: 10.1038 / ijo.2012.197.
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