Umvuzo Ongafanelekiyo Wesekethe kwi-Obsessive Compulsive Disorder

Abasebenzisa iphonografi bahlala bexela ukonyuka kohlobo lwe-OCD yokucinga, mhlawumbi ngenxa ye-dopamine dysregulation

2011 Meyi 1;69(9):867-74. doi: 10.1016/j.biopsych.2010.12.003.

UMGQUBO: I-Obsessive-compulsive disorder (OCD) ikakhulu ithathwa njengengxaki yokuxhalaba kodwa ineempawu ezifana nokuziphatha okukhobokisayo. Izigulana ezine-OCD zinokukhula ukuxhomekeka kwindlela yokuziphatha enyanzelekileyo ngenxa yeziphumo ezinomvuzo emva kokuncipha koxinzelelo olubangelwa kukuxhalaba. Ukusetyenzwa kwembuyekezo kuxhomekeke kakhulu kumjikelezo we-ventral striatal-orbitofrontal kunye nezifundo zokucinga ngengqondo kwi-OCD zihlala zibonisa ukusebenza okungaqhelekanga ngaphakathi kwesi sekethe. Esi sisifundo sokuqala sokucinga esisebenzayo sokuphanda ngokucacileyo ukujikeleza okuvuza kwi-OCD.

IINDLELA: Umsebenzi wobuchopho ngexesha lokulindela umvuzo kunye nokufunyanwa kwathelekiswa phakathi kwezigulane ze-18 ze-OCD kunye nezifundo zokulawula ezinempilo ze-19, usebenzisa umsebenzi wokulibaziseka wemali kunye ne-imaging magnetic resonance resonance. Ukusetyenzwa kwembuyekezo kwathelekiswa phakathi kwezigulana ze-OCD ezinoloyiko olukhulu lokungcoliseka kunye nezigulana ezinovavanyo olunomngcipheko ophezulu kakhulu.

IINKCUKACHA: Izigulana ze-Obsessive-compulsive disorder zibonise umsebenzi wokulindela umvuzo ophantsi kwi-nucleus accumbens xa kuthelekiswa nezifundo zolawulo olunempilo. Umsebenzi ocuthiweyo we-nucleus accumbens wachazwa ngakumbi kwizigulana ze-OCD ezinoloyiko lokungcoliseka kunezigulana ezinovavanyo oluphezulu lwengozi. Umsebenzi wobuchopho ngexesha lokufumana umvuzo wawufana phakathi kwezigulane kunye nezifundo zokulawula. Icebiso elibhekiselele ekuqhubekekeni komvuzo ongasebenziyo lifunyenwe kwizigulana ze-OCD ezinganyangekiyo kunyango abathi emva koko baphathwa ngempumelelo ngovuselelo olunzulu lobuchopho be-nucleus accumbens.

IMISEBENZI: Izigulana ze-Obsessive-compulsive disorder zisenokungakwazi ukwenza ukhetho oluluncedo ngenxa yokuguqulwa kwe-nucleus accumbens activation xa ulindele umvuzo. Oku kufunyanisiweyo kuxhasa ingqikelelo ye-OCD njengokuphazamiseka kokusetyenzwa komvuzo kunye nokuba likhoboka lokuziphatha.