Psychoneuroendocrinology. 2015 Nov;61:53. doi: 10.1016/j.psyneuen.2015.07.534. Epub 2015 Aug 8.
Chatzittofis A1, UArver S1, Öberg K1, Hallberg J1, Nordström P1, UJokinen J.
Iimbalasane
- Amadoda ane-hypersexual disorder ayenezinga eliphezulu le-DST yokungacinezeli kunolawulo.
- Amadoda ane-hypersexual disorder ayenamanqanaba aphezulu e-DST-ACTH xa kuthelekiswa nolawulo.
Abstract
Ukuphazamiseka kwe-Hypersexual edibanisa imiba ye-pathophysiological efana nokupheliswa komnqweno wesini, ukuba likhoboka lezesondo, ukungalawuleki kunye nokunyanzeliswa kwacetyiswa njengoxilongo lwe-DSM-5. Nangona kunjalo, kuncinci okwaziwayo malunga ne-neurobiology emva kwesi sifo. I-dysregulation ye-hypothalamic pituitary adrenal (HPA) axis ibonakalisiwe kwingxaki yengqondo kodwa ayizange iphandwe kwi-hypersexual disorder. Injongo yolu phononongo yayikukuphanda umsebenzi we-axis ye-HPA kwi-hypersexual disorder.
Uphononongo lubandakanya izigulane ze-67 ezingamadoda ane-hypersexual disorder kunye ne-39 yamavolontiya angamadoda anempilo. Amanqanaba e-plasma ye-basal ekuseni ye-cortisol kunye ne-ACTH yavavanywa kwaye i-dose ephantsi (0.5 mg) uvavanyo lokunciphisa i-dexamethasone lwenziwa nge-cortisol kunye ne-ACTH ilinganisa ukulawulwa kwe-postdexamethasone. Isimo sokunganyanzelisi sichazwe ngamanqanaba e-DST-cortisol ≥138 nmol / l. Isikali seSexual Compulsive Scale (SCS), Hypersexual disorder assessment scale yangoku (HD:CAS), Montgomery-Åsberg Depression Scale-self rating (MADRS-S) kunye ne-Childhood trauma questionnaire (CTQ), zazisetyenziselwa ukuvavanya ukuziphatha kwe-hypersexual, ukuqina koxinzelelo kunye ubunzima bobomi bokuqala.
Izigulana ezine-hypersexual disorder zazidla ngokuphindaphindiweyo nge-DST ezingacinezeli kwaye zinezinga eliphezulu kakhulu le-DST-ACTH xa kuthelekiswa namavolontiya asempilweni. Izigulana zichaze kakhulu ukwenzakala kwabantwana kunye neempawu zokudakumba xa kuthelekiswa namavolontiya asempilweni. Amanqaku e-CTQ abonise ukulungelelaniswa okungalunganga okubalulekileyo kunye ne-DST-ACTH ngelixa i-SCS kunye ne-HD: Amanqaku e-CAS abonisa ukulungelelaniswa okungalunganga kunye ne-cortisol yokuqala kwizigulane. Ukuxilongwa kwe-hypersexual disorder kwakunxulunyaniswa kakhulu ne-DST yokungacinezeli kunye ne-plasma ephezulu ye-DST-ACTH naxa ilungiselelwe ukwenzakala kwabantwana.
Iziphumo zibonisa i-HPA axis dysregulation kwizigulana zamadoda ezine-hypersexual disorder.
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