Umlutha weBool. 2015 Jul;20(4): 820-31. doi: 10.1111/adb.12162. Epub 2014 Sep 11.
Elton A1, USmitherman S2, Umncinci uJ2, Iikhithi zeCD2.
Abstract
Inkxwaleko yobuntwana inefuthe elibi kuzo zonke izigaba zenkqubo yokulutha kwaye inxulunyaniswa notshintsho oluqhubekayo kwi-neuroendocrine, i-autonomic kunye neempendulo zengqondo kuxinzelelo. Sazama ukubonisa impembelelo yokuxhatshazwa kwabantwana kunye nokungahoywa kwi-neural correlates yoxinzelelo- kunye neziyobisi ezibangelwa kukunqwenela iziyobisi ezinxulumene nokuba likhoboka le-cocaine. Amadoda axhomekeke kuCocaine ane (n = 20) nangaphandle (n = 18) imodareyitha ukuya kwimbali yokuphathwa gadalala ebuntwaneni aye afumana umfanekiso-ngqondweni osebenzayo wemagnethi ngexesha lomfanekiso wengqondo okhokelwa ngumbhalo woxinzelelo lomntu, ukusetyenziswa kweziyobisi kunye namava angathathi hlangothi.
Xa kuthelekiswa neskripthi esingathathi hlangothi, uxinzelelo kunye nemibhalo yokusetyenziswa kweziyobisi isebenze i-striatal, i-prefrontal, i-posterior cingulate, imimandla yesikhashana kunye ne-cerebellar ehambelana nezifundo zangaphambili zelizwe elinyanzeliswayo loxinzelelo kunye nokunqwenela iziyobisi. Kwiskripthi soxinzelelo, amadoda aphathwa kakubi abonise ukusebenza okuncitshisiweyo kwe-anterior precuneus kunye nommandla wemoto eyongezelelweyo (SMA); Ukusebenzisana kobungqongqo bempatho-gadalala kunye neempendulo zokunqwenela ezibangelwa luxinzelelo kuqikelelwe ukuba kusebenze i-rostral yangaphambili ye-cingulate cortex encinci. Kwiskripthi sokusetyenziswa kweziyobisi, amadoda aphathwe kakubi abonise ukusebenza okukhulu kwe-dorsolateral prefrontal cortex. Ukusebenzisana kobungqongqo bokuphathwa gadalala kunye neempendulo ezinqwenelekayo zinxulunyaniswa nokusebenza okukhulu kwe-cortex ebonakalayo kunye ne-SMA, ngelixa isiphumo sokuphatha kakubi-nge-anxiety sibandakanya ukusebenza kancinci kwe-ventromedial prefrontal cortex.
TIziphumo zibonisa umbutho wokuphathwa gadalala kwabantwana kunye nokunyuka kolangazelelo lokusabela kwiindlela zeziyobisi kunye nokuncipha kokubandakanyeka kweenkqubo zokulawula kunye nokulawulwa kwezenzo zokuphendula kuxinzelelo- okanye iziyobisi ezibangwa kukunqwenela iziyobisi kunye neempendulo zoxinzelelo kumadoda axhomekeke kwi-cocaine. Ezi zinto zifunyanisiweyo zibonelela ngolwazi oluyinoveli kwiindlela zobuchopho ezinokubakho apho ukuphathwa kakubi kwabantwana kwandisa umngcipheko wokuphinda ubuyele kubomi babantu abaxhomekeke kumachiza.
IINKCUKACHA:
Ubukhoboka; ukuphathwa gadalala ebuntwaneni; icocaine; iimpawu zeziyobisi; fMRI; uxinzelelo
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