I-Psychopharmacology (Berl). 2003 Okt;170(1):62-72. Epub 2003 Jul 4.
ISinha R1, Talih M, Malison R, Cooney N, Anderson GM, Kreek MJ.
Abstract
INDLELA YOKUZIPHATHA:
Izivuseleli zokusingqongileyo ezinxulunyaniswa ne-cocaine ziyaziwa ngokuvusa ukunqwenela iziyobisi kunye nokwandisa amathuba okuphinda abuyele. Nangona kunjalo, utshintsho lwengqondo yengqondo eyenzeka ngokuvezwa kwezi zivuseleli kunye nakwiziqephu zokunqwenela iziyobisi aziqondwa kakuhle. Olu phononongo luvavanye impendulo yeesekethe zoxinzelelo lobuchopho kwisivuseleli sendalo esaziwa ngokunyusa inkanuko ye-cocaine kubantu abaxhomekeke kwi-cocaine.
IINDLELA:
Amashumi amahlanu anesine onyango olufuna abantu abaxhomekeke kwi-cocaine, abathe bamkelwa kwicandelo lophando lonyango lwezigulana ezingalaliswayo kangangeeveki ezi-2 ukuya kwezi-4, bathathe inxaxheba kwiiseshoni ezintathu zaselabhoratri. Izifundo zibonakaliswe kumfanekiso omfutshane we-5-min ekhokelwayo ebandakanya ukucinga imeko yamva nje yoxinzelelo lomntu, imeko enxulumene neziyobisi kunye nemeko yokuphumla engathathi hlangothi, umfanekiso omnye ngeseshoni oboniswe ngokulandelelana okungahleliwe. Ukulinganisa okuphantsi kokunqwenela kunye nokuxhalaba, amanyathelo e-cardiovascular, kunye namanqanaba e-plasma ye-adrenocorticotrophic hormone (ACTH), i-cortisol, i-prolactin, i-norepinephrine (NE) kunye ne-epinephrine (EPI) yavavanywa.
IINKCUKACHA:
Ukuvezwa kuxinzelelo kunye neempawu zeziyobisi nganye kubangele ukonyuka okubonakalayo kokunqwenela i-cocaine kunye noxinzelelo oluzimeleyo, izinga lepulse, uxinzelelo lwegazi lwe-systolic, i-ACTH, i-cortisol, i-prolactin kunye ne-NE xa kuthelekiswa nempendulo kwimifanekiso engathathi hlangothi. Ukongeza, imifanekiso yoxinzelelo ikwanyuse uxinzelelo lwegazi lwe-diastolic kunye ne-plasma ye-EPI xa kuthelekiswa neempendulo kumfanekiso we-chiza kunye nemifanekiso epholileyo engathathi hlangothi.
IMISEBENZI:
Iziphumo zibonisa ukusebenza okubalulekileyo kwe-CRF-HPA axis kunye ne-noradrenergic/sympatho-adreno-medullary (SAM) impendulo yenkqubo ngexesha loxinzelelo-olubangelwa kunye neziyobisi ezibangela ukunqwenela i-cocaine kubantu abaxhomekeke kwi-cocaine. Indima yokusebenza kwenkqubo yoxinzelelo kumnqweno we-cocaine kunye nokusetyenziswa kwe-cocaine kuyaxoxwa.
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