Biol Psychiatry. I-2019 Dec 24. pii: S0006-3223 (19) 31959-6. doi: 10.1016 / j.biopsych.2019.12.018.
Birie MT1, I-Kooiker CL2, Ngokufutshane i-AK1, IBolton JL1, U-Chen Y1, I-Baram TZ3.
Abstract
Ukuphazamiseka ekusebenzeni komjikelezo womvuzo uphantsi kwemiba emininzi yokuphazamiseka. Ukuphazamiseka okunjalo kunokubonakalisa njengokuziphatha okufudukayo kubandakanya ukuthatha umngcipheko, uxinzelelo, isifo sokudumba, kunye neziyobisi. Ubunzima bexesha lobomi obuqhelekileyo yinto eqhelekileyo yokuchaphazeleka kolutsha nokuphazamiseka kwabantu abadala okubandakanya ukujikeleza komvuzo. Nangona kunjalo, nokuba ngaba ubunzima obusebusweni bakho buchaphazela uguquko kunye nokusebenza komjikelezo womvuzo, kunye neendlela ezinokubakho, hlala ungacacanga. Apha, sibonisa ulwazi lwenoveli kusetyenziswa ubuchwepheshe obunqamlezayo kwiimodeli zezilwanyana ukukhupha iindlela apho ubunzima obusebusweni budala bukwenza ukuba kungabikho kusebenzisana okunzima koxinzelelo kunye nemijikelezo yomvuzo. Sicebisa ukuba iindlela ezithile ezichazwe zimolekyuli ngaphakathi kwendlela yokuhamba komvuzo zichaphazeleka ikakhulu kukubandezeleka kobomi bokuqala. Siphonononga imimandla kunye neendlela ezibonisa uxinzelelo lwepeptide corticotropin-ukukhulula into (CRF), ebonakaliswe kwizinto ezibaluleke kakhulu kumjikelezo womvuzo kunye nokujikeleza koxinzelelo. Ngokukodwa, i-CRF iguqulwe ngokuqinile kukubandezeleka kobomi bokuqala kwimimandla emininzi yengqondo. Ukugxila kwi-amygdala nuclei kunye noqikelelo lwabo, sinikezela ubungqina obucebisa ukuba ukuhanjiswa kwe-CRF kunye nomsebenzi unokuwenza ungaphantsi kwendibaniselwano engalunganga yeeseli ze-nucleus ngeendawo zokoyika / zinexhala, ukuphazamisa ukusebenza kwale ndawo ibalulekileyo yolonwabo kunye nomvuzo.
IINKCUKACHA: Iziyobisi IAmygdala; Anhedonia; I-CRH; Iinyukliyitha; Uxinzelelo
PMID: 32081365
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