Utywala lweeNkcazo zoTywala. 2014 Nov;38(11):2770-9. doi: 10.1111/acer.12555.
Karkhanis AN1, Lokhi JL, McCool BA, Weiner JL, I-Jones SR.
Abstract
UMGQUBO:
Uxinzelelo kubomi bakwangoko lunxulunyaniswa nokwanda kokuba sesichengeni kubukhoboka botywala. Nangona kunjalo, i-neural substrates enxibelelanisa uxinzelelo olungapheliyo lobuntwana/lokufikisa kunye nomngcipheko owonyukayo wokukhotyokiswa butywala awaqondwa kakuhle. Kwi-nucleus accumbens (NAc), i-dopamine (DA) kunye ne-norepinephrine (NE) ukubonakaliswa kunokuphenjelelwa kakhulu luxinzelelo, ukuxhalaba, kunye neziyobisi zokuxhatshazwa, kubandakanya i-ethanol (EtOH). Apha, siqeshe imodeli ye-rodent yoxinzelelo kubomi bangaphambi kwexesha ekhokelela ekunyamezeleni ukonyuka kokuziphatha okusemngciphekweni wokunxila ukuze siqonde ngcono ukuba uxinzelelo olungapheliyo lokufikisa lunokuchaphazela njani ubuntununtunu be-EtOH ye-DA kunye ne-NE ukukhululwa kwi-NAc.
IINDLELA:
Iigundane ze-Male Long-Evans zazihlala kwiqela (GH; i-4 iigundane / i-cage) okanye i-socially (SI; i-1 irat / i-cage) kwiiveki ze-6 eziqala ngosuku lokubeleka 28. Iigundane ze-SI kunye ne-GH zavavanywa ekukhuleni kwabantu abadala ngenxa yokuziphatha okuxhalabisayo. (ephakanyisiweyo kunye ne-maze), kunye nemiphumo ye-EtOH (1 kunye ne-2 g / kg; i-intraperitoneally.) kwi-NAc DA kunye ne-NE zavavanywa nge-microdialysis.
IINKCUKACHA:
Izilwanyana ze-SI zibonise ukunyuka kokuziphatha okuxhalabisayo xa kuthelekiswa nezilwanyana ze-GH. Nangona i-SI yayingenayo impembelelo kumanqanaba asisiseko e-DA okanye i-NE, amanqanaba esiseko e-DA aye adityaniswa ngokufanelekileyo kunye namanyathelo okuxhalaba. Ukongezelela, ngelixa kungekho ntlukwano ebalulekileyo ebonwe nge-1 g / kg EtOH, i-2 g / kg idosi ibangele ukukhululwa okukhulu kwe-DA kwizilwanyana ze-SI. Ngaphezu koko, i-EtOH (2 g / kg) iphakamise kuphela amanqanaba e-NAc NE kwiigundane ze-SI.
IMISEBENZI:
Ezi ziphumo zibonisa ukuba uxinzelelo olungapheliyo lobomi bokuqala lukhuthaza i-accumbal DA kunye ne-NE ukukhululwa ekuphenduleni umngeni we-EtOH onzima. Uvakalelo olukhulu lwe-EtOH ye-DA kunye ne-NE yokukhululwa kwe-dynamics kwi-NAc inokufaka isandla ekwandeni kwezinto ezinobungozi bokuziphatha kotywala, njengokuzilawula okukhulu kwe-EtOH, ezibonwa kwiigundane ze-SI.
Ilungelo lokushicilela © 2014 nguMbutho woPhando ngoTywala.
IINKCUKACHA:
iDopamine; I-Ethanol; Norepinephrine; I-Nucleus Accumbens; Ukubekwa wedwa koluntu
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