J Neurosci. 2014 Apr 2;34(14):5012-22. doi: 10.1523/JNEUROSCI.3707-13.2014.
Furlong TM1, Jayaweera HK, Balleine BW, Corbit LH.
Kudalirika
Kufikira zakudya zokoma komanso zopatsa mphamvu kumathandizira kukulitsa kunenepa padziko lonse lapansi. Ena apanga mkangano wotsutsana kuti kumwa zakudya zotere kumatha kuyambitsa "chizolowezi chodya," komabe sizikudziwika kwenikweni za kutalika kwa nthawi yayitali zakudya zokoma kungasinthe kuphunzira komwe kumayendetsedwa ndi zolinga komanso kupanga zisankho.
Muzitsulo zotsatirazi, makoswe anapatsidwa masabata a 5 opitilira tsiku lililonse kapena oletsedwa mkaka wosakanizidwa wokoma (SCM) musanayambe maphunziro opangira chakudya. Pambuyo pake tinayesa ngati zolinga zogwiritsidwa ntchito zowonongeka zinali zovuta m'magulu awa pogwiritsa ntchito zotsatira-ntchito yoyeretsera. Makoswe ochepetsedwa amachepetsa kuyankha potsatira kuwunika kwa zotsatira monga momwe adachitira anthu omwe anali ndi mwayi wopita ku SCM. Zokondweretsa, makoswe omwe anali ndi mwayi wopita ku SCM osagwiritsidwa ntchito movomerezeka amavomerezanso mofanana ndi zikhalidwe zowonongeka ndi zowonongeka, zomwe zikuwonetsa kutayika kwa cholinga-kulamulidwa koyankhidwa. Kuwona ngati kutaya kwa cholinga-chotsogolera chotsogolera chinali limodzi ndi kusiyana kwa ntchito za neuronal, tinagwiritsira ntchito c-Fos immunohistochemistry kuti tione njira zowonjezera panthawi yoyezetsa magazi. Tinawona kwambiri c-Fos immunoreactivity mu dorsolateral striatum (DLS) ndi madera ozungulira omwe ali nawo omwe adalandira mwayi wodalirika wopezeka ku SCM ndipo amasonyeza kusowa mtima kwa chiwonongeko cha zotsatira. Kulowetsedwa kwa wotsutsa AMPA-receptor wotsutsa CNQX kapena Dopamine D1-receptor wotsutsa SCH-23390 ku DLS musanayese kuyesa kubwezeretsedweratu cholinga-gulu lotetezedwa ku SCM, kutsimikizira kuti dera lino ndilofunika kuti chizoloŵezi chokhazikika. Zotsatira izi zikuwonetsa kuti zakudya zam'mbuyomu zingasinthe kuphunzira koyamba ndi ntchito m'mipata ya neural yomwe imathandizira ntchito.
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