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Harrold JA 1 , Elliott JC , King PJ , Widdowson PS , Williams G.
Kudalirika
Agonists ku cannabinoid-1 (CB-1) zolandilira zimalimbikitsa kudyetsa ndipo makamaka zimalimbikitsa mphotho pakudya. Kuti tifufuze ngati zotheka cannabinoids zingayambitse chilakolako cha chakudya chokoma, tinafanizira kuchuluka kwa cholandilira cha CB-1 mu forebrain ndi hypothalamus, pakati pa makoswe omwe amadyetsa chow yoyenera (n = 8) ndi ena omwe amapatsidwa chakudya chokoma (n = 8) kwa milungu 10 kunenepa kwambiri. Kuchuluka kwa cholandirira cha CB-1 kunachepa kwambiri ndi 30-50% (P <0.05) mu hippocampus, cortex, nucleus accumbens ndi gawo la entopeduncular la makoswe odyetsedwa.
Kuphatikiza apo, kuchuluka kwa ma receptor a CB-1 mu hippocampus, nucleus accumbens ndi entopeduncular nucleus kunali kogwirizana kwambiri ndi kudya chakudya chokoma (r(2)=0.25-0.35; onse P<0.05). Mosiyana ndi zimenezi, kumangirira kwa receptor ya CB-1 mu hypothalamus kunali kochepa ndipo sikunasinthe mwa makoswe omwe amadya zakudya. Kutsika kwa receptor ya CB-1 kumagwirizana ndi kuwonjezeka kwa kuyambika kwa ma receptor awa ndi ma cannabinoids achilengedwe. Pogwira ntchito m'malo monga nucleus accumbens ndi hippocampus, omwe amagwira ntchito m'mbali zosiyanasiyana za kudya, ma cannabinoids amatha kuyambitsa chilakolako cha chakudya chokoma motero amazindikira kuchuluka kwa mphamvu zomwe munthu amadya komanso kuopsa kwa kunenepa kwambiri komwe kumabwera chifukwa cha kudya. Komabe, ma cannabinoids mu hypothalamus sakuwoneka kuti akukhudza mbali iyi ya khalidwe la kudya.
PMID: 12376184