Resin ya ubongo. 2002 Oct 18;952(2):232-8.
Harrold JA1, Elliott JC, Mfumu PJ, Widdowson PS, Williams G.
Kudalirika
Agonists ku cannabinoid-1 (CB-1) zolandilira zimalimbikitsa kudyetsa ndipo makamaka zimalimbikitsa mphotho pakudya. Kuti tifufuze ngati zotheka cannabinoids zingayambitse chilakolako cha chakudya chokoma, tinafanizira kuchuluka kwa cholandilira cha CB-1 mu forebrain ndi hypothalamus, pakati pa makoswe omwe amadyetsa chow yoyenera (n = 8) ndi ena omwe amapatsidwa chakudya chokoma (n = 8) kwa milungu 10 kunenepa kwambiri. Kuchuluka kwa cholandirira cha CB-1 kunachepa kwambiri ndi 30-50% (P <0.05) mu hippocampus, cortex, nucleus accumbens ndi gawo la entopeduncular la makoswe odyetsedwa.
Kuwonjezera apo, chiwerengero cha CB-1 chotsatira mu hippocampus, nucleus accumbens ndi entopeduncular nucleus zinali zosiyana kwambiri ndi kudya chakudya chokoma (r (2) = 0.25-0.35; zonse P <0.05). Mosiyana ndi izi, cholandirira cha CB-1 chomanga mu hypothalamus chinali chotsika ndipo sichinasinthidwe ndi makoswe odyetsedwa. Kutsika kwa CB-1 kulandila malamulo kumagwirizana ndi kuwonjezeka kwa kutsegulira kwa ma receptors ndi ma cannabinoids amkati. Kuchita zinthu kumadera monga nucleus accumbens ndi hippocampus, zomwe zimakhudzana ndi kudya, zida zowonongeka zimatha kuyambitsa chakudya chokhutiritsa ndipo potero zimakhala ndi mphamvu yowonjezera mphamvu komanso kulemera kwa zakudya zomwe zimadetsa kwambiri. Komabe, zoperewera zam'madzi mu hypothalamus siziwoneka kuti zimakhudza mbali iyi ya kudya.
PMID: 12376184
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