Zotsatira zokhumba zokhudzana ndi shuga pa maonekedwe a jini m'madera opindula a ubongo (2014)

Mankhwala osokoneza bongo ndi anthu amaganiziridwa kuti agwiritse ntchito malo omwe amachititsa ubongo kuti agwirizane ndi ziwalo zofunikira, monga kudya.

INthandizi ya izi, timalongosola apa kuti zigawo zomwe zimayambitsa shuga zimadalira kusintha kwa dopamine ndi opioid mRNA zomwe zimakhala ngati makoswe a morphine. Mwachindunji, pambuyo pa nthawi yambiri yophatikizapo mankhwala ochepa pa mankhwala a sucrose, maselo a mRNA a D2 dopamine receptor, ndipo majeremusi a preproenkephalin ndi preprotachykinin adachepetsedwa m'madera ozungulira a dopamine, pamene D3 dopamine receptor mRNA yowonjezera.

Ngakhale kuti morphine imakhudza majini pamtundu wonse wa dopamine-recepttive striatum, kusiyana kwakukulu kunawoneka pa zotsatira za shuga pa nucleus accumbens ndi pafupi-caudate-putamen. Zotsatira za shuga pamagulu a mRNA zinali zazikulu kwambiri mu nucleus accumbens kuposa mu caudate-putamen. Maderawa adawonetsanso kusiyana kosiyana pakati pa ma jini, makamaka pakati pa D3R ndi majini ena. Izi zinawululidwa ndi njira ya multivariate yowonetsera njira zomwe zimagwirizanitsa mgwirizano pakati pa majini, makamaka mu nucleus accumbens koma osati caudate-putamen. Pomalizira, gawo la kugwirizanitsa ntchito kotereku kugawidwa kwa magawo okhudzidwa chifukwa cha shuga kunathandizidwa ndi kupeza njira yosiyana pakati pa majini m'madera awiri othawa.

Tzofufuza zonsezi zimathandizira mbali yaikulu yomwe chigawochi chimagwiritsidwa ntchito pothetsa zotsatira za zinthu zowonongeka mwachilengedwe ndi kukulitsa chitsanzo cha zinyama pophunzira gawo lodziwika la mankhwala osokoneza bongo ndi matenda odwala.