Psychopharmacology (Berl). 2015 Jun 20.
Janssen LK1, Sescousse G, Hashemi MM, Timmer MH, Ter Huurne NP, Amakhala DE, Amazizira R.
Kudalirika
RATIONALE:
Kutchova njuga kwachikhalidwe kumalumikizidwa ndi matenda opatsirana a dopamine, makamaka kuperewera kwa dopamine D2-receptor, komanso kusinthanso kuphunzira. Kuphatikiza apo, nkhani zambirimbiri zam'mawu zikusonyeza kuti gawo lofunikira kwambiri kuti dopamine isinthidwenso ndi kuphunzira. Komabe, palibe umboni wowonetsa kuti pali kulumikizana mwachindunji pakati pa dopamine, kuphunzira mobwerezabwereza ndi njuga ya pathological.
KUCHITA:
Cholinga cha phunziroli lilipo pano ndikuwongolera dopamine, kuphunzira mobwerezabwereza, komanso kutchova njuga.
ZITSANZO:
Apa, timayesa lingaliro loti kutchova juga kwa matenda am'thupi kumatsagana ndi zovuta zokhudzana ndi dopamine ndikuphunzira pamalipiro ndi chilango pofufuza zotsatira za dopamine D2-receptor antagonist sulpiride (400 mg) pamalipiro- ndikubwezereranso potengera maphunziro mu 18 otchova njuga ndi 22 zowongolera zathanzi, pogwiritsa ntchito njira yolamulidwa ndi placebo, yakhungu lachiwiri, yotsutsana.
ZOKHUDZA:
Pogwirizana ndi maphunziro am'mbuyomu, blockade ya D2 receptors yokhala ndi mphotho yoyipa yolimbana ndi maphunziro obwezera m'malamulo. Mosiyana ndi izi, sulpiride sinakhale ndi zotsatila zotsatidwa ndi otchova njuga.
POMALIZA:
Izi zimawonetsa kuti njuga zamatenda zimalumikizana ndi dopamine yokhudzana ndi dopamine pakusinthanso maphunziro kuchokera pamalipiro ndi chilango.
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