MAFUNSO: Zimandivuta kukhulupirira kuti dopamine sakuphatikizidwa, monga momwe olemba akunenera. Choyamba, adagwiritsa ntchito mdani wa D2. Nanga bwanji kuyambitsidwa kwa D1 komwe ndikofunikira kwambiri pakulimbikitsa? Komanso, tikudziwa kuti kulimbikitsidwa kumaphatikizapo PFC ndi amygdala glutamate zolowetsa zomwe zimagwira NaC. Kodi ndi glutamate wothandizira ma D1 receptors? Koma pano pali kusiyana kwakukulu pamalingaliro: pomwe zophonya pafupi ndizo "ZOPindulitsa kwambiri" kwa omwe ali ndi vuto la kutchova juga, zoperewera pafupi sizowona mphoto - kupambana ndiko. Dopamine amagwa pomwe zoyembekezera sizikukwaniritsidwa. Chiyembekezo pa nkhaniyi chikupambana.
Guillaume Sescousse1,2, Lieneke K Janssen1,2, Mahur M Hashemi1, Wolemba Monique HM Timmer1,3,4, Dirk EM Maulendo1,2, Niels P ter Huurne1,2, Luke Clark3,4 ndi Roshan Cools1,2
- 1Donders Institute for Brain, Cognition and Behaeve, Radboud University, Nijmegen, Netherlands
- 2Dipatimenti ya Psychiatry
- 3Dipatimenti ya Neurology, Radboud University Medical Center, Nijmegen, Netherlands
- 4Center for Joker Research ku UBC, dipatimenti ya Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Ulembedwe: Dr G Sescousse, Donders Center for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behavior, Radboud University, Kappitelweg 29, PO Box 9101, Nijmegen 6500 HB, the
Netherlands, Tel: + 31 0 24 36 10618, Fax: + 31 0 24 36 10989, E-mail: [imelo ndiotetezedwa]
Kudalirika
Zomwe zatsala pang'ono pamasewera a juga zikutaya zochitika zomwe zimayandikira kupambana. Zomwe zaphulika kale zidawonetsedwa kale kuti zikulandila zigawo zamaubongo zokhudzana ndi mphotho kuphatikiza gawo laling'ono lamkati, komanso kulimbikitsa kutchova juga, zomwe zikuwoneka kuti zidayambitsa kubodza. Popeza kuti otchova njuga amakhala pachiwopsezo chachikulu chazinyengozi, chizolowezi chawo chotchova juga chitha kubwera chifukwa cha chidwi champhamvu chofika kumapeto. Kuphatikiza apo, kafukufuku wazinyama adawonetsa kuti mayankho a zochitika zaposachedwa-posachedwa amakhudzidwa ndi dopamine, koma kukopa kwa dopaminergic sikunayesedwe mwa anthu. Kuti mufufuze izi, tidayeseza otsogola a 22 oyang'anira ndi ma 22 oyang'anira athanzi omwe amasewera makina olowetsa anthu, ma fayilo oyandikira ndi kuphonya kwathunthu, mkati mwa chosakira cha FMRI. Wophunzira aliyense adasewera ntchitoyi kawiri, kamodzi pansi pa placebo komanso kamodzi pansi pa dopamine D2 receptor antagonist (sulpiride 400 mg), mumapangidwe amaso awiri, osasokoneza. Ophunzira adafunsidwa kuti awalimbikitse kupitiriza kutchova juga pantchito yonse. Pagulu lonse lochita nawo gawo, omwe ali pafupi nawo adalimbikitsa chidwi chofuna kupitiriza kutchova njuga ndikuwonjezera mayankho abwinobwino poyerekeza ndi zoperewera. Mwachisoni, otchova juga wazomwe adawonetsa mayankho omwe adakwezedwa kwa zoyipa zapafupi poyerekeza ndi zowongolera. Kusiyanaku kwamagulu sikunawonedwe kutsatira zotsatira zopambana. Mosiyana ndi zomwe timaganiza, sulfide sanapangitse njira yodalirika yamafotokozedwe aubongo posachedwa. Zonsezi, zotsatira zathu zikuwonetsa kuti otchova juga adakulitsa kuyankha kwa ubongo kuzomwe zakuphonya, zomwe zimapangitsa kuti azichita njuga mosalekeza. Komabe, palibe umboni kuti mayankho amenewa amakhudzidwa ndi dopamine. Zotsatira izi zimakhudza kayendedwe ka chithandizo ndi malamulo a njuga.
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