Biol Psychol. 2010 Sep;85(1):33-7. doi: 10.1016/j.biopsycho.2010.04.008.
Lobo DS1, Souza RP, Tong RP, Casey DM, Hodgins DC, Smith GJ, Williams RJ, Schopflocher DP, Wood RT, el-guebaly n, Kennedy JL.
Kudalirika
Pathological njuga (PG) ndizovuta kuzilamulira zomwe zili ndi chiopsezo cha chibadwa. Tidawunikira mayanjano amtundu wamtundu wa dopaminergic receptor genes (DRD1-3s) ndi chiopsezo chotchova juga m'maphunziro athanzi pogwiritsa ntchito Canadian Problem Gging Index (CPGI). Maphunziro a Health a Caucasian omwe adatchova juga kamodzi kamodzi pamoyo wawo (n = 242) adaphatikizidwa pakuwunikira. Jenda siinalumikizidwe ndi CPGI, pomwe unyamata wawung'ono unalumikizidwa ndi zambiri m'maphunziro a CPGI. Tapeza kuti palibe ma polymorphisms amodzi omwe amafufuzidwa pa DRD1 ndi DRD3 omwe adalumikizidwa ndi kuchuluka kwa CPGI m'maphunziro athanzi. Komabe, tidawona zomwe zikuchitika pakubwera pa polymorphism ya TaqIA / rs1800497 (P = 0.10) ndi haplotype Flanking DRD2 (G / C / A rs11604671 / rs4938015 / rs2303380; P = 0.06). Makhalidwe onsewa adalumikizidwa ndi m'munsi CPGI. Zotsatira zathu zimaperekanso umboni wina wokhudzana ndi dopamine D2-ngati receptor pakukakamira.
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