J Psychopharmacol. 2015 Jul 7. pii: 0269881115592338. [Epub patsogolo posindikiza]
Zack M1, Boileau I2, Payer D2, Chugani B2, Lobo DS2, Houle S2, Wilson AA2, Warsh JJ2, Kish SJ2.
Kudalirika
Kusokonezeka kwa mtima ndi hypothalamic pituitary axis (HPA) kwawonedwa mwa anthu omwe ali amisala otsegula m'magazi (PGs). Izi mwina zimachokera pakukhudzidwa ndi juga nthawi zonse. Kuyankha kwa amphetamine (AMPH) kungavumbulutse zosokoneza zoterezi pakumayang'anira mayankho osakanikirana ndi kutchova juga mu ma PGs vs maulamuliro athanzi (HCs).
Kafukufukuyu adayeza kuchuluka kwa mtima (HR), magazi a systolic (SBP) komanso kuthamanga kwa magazi kwa diastolic (DBP) ndi plasma cortisol kutsatira AMPH (0.4 mg / kg) mu ma PG amuna (n = 12) ndi HCs (n = 11) omwe adayang'ana positron emission tomography (PET). Ntchito ya Stop Signal Task inathandiza kuyesa kulumikizana komwe kulipo pakati pathupi ndi chikhalidwe. Zotsatira zoyeserera zinasanthulidwa.
Mayankho a ma PG ku AMPH anali osiyana ndi a HC pa index iliyonse.
Ma PG adawonetsa kukwezeka kosalekeza mu DBP ndikuchepetsa kopitilira mu HR (mwachitsanzo, baroreflex) poyerekeza ndi ma HC oposa 90 min post-kipimo. Ma PG adawonetsa zoperewera mu cortisol poyerekeza ndi ma HC omwe adasinthidwa pang'ono ndi AMPH. Zowonongeka pa Stop Signal Task zikugwirizana bwino ndi HR mumawongoleredwe, koma molakwika ndi HR mu PGs, ndikuwonetsa kuti poyambira mwamphamvu komanso mokakamiza kuyankha kotsitsimutsa aliyense angalosere za kufalitsa matenda. Zowonjezera zinaneneratu za kuyatsira kwakanthawi mu ma PG. Kusokonezedwa kwa Noradrenergic kumatha kuyambitsa mayankho omveka ku zovuta zotsitsimutsa komanso kudziwitsa ma PG.
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