Mu vivo umboni wa amphetamine omwe amachititsa kuti dopamine amasulidwe kutchova njuga: positron emission tomography kuphunzira ndi [(11) C] - (+) - PHNO (2014)

Kuledzera kwa mankhwala osokoneza bongo kwayenderana ndi kuchepa kwa ntchito ya mesostriatal dopamine (DA), koma ngati dziko lino limafikira pazolankhula zamtunduwu monga njuga ya pathological (PG) sizikudziwika. Apa tidagwiritsa ntchito positron emission tomography ndi D3 receptor-prefer radioligand [(11) C] - (+) - PHNO panthawi ya protocol yoyendera ziwiri kuti afufuze kumasulidwa kwa DA poyankha amphetamine wamlomo m'matayala a pathological (n = 12) komanso athanzi zowongolera (n = 11). Mosiyana ndi zomwe anthu adapeza pakupeza mankhwala osokoneza bongo, timapereka umboni woyamba kuti PG imagwirizanitsidwa ndi kutulutsidwa kwakukulu kwa DA mu dorsal striatum (54-63% Greater [(11) C] - (+) - PHNO kusamutsidwa) kuposa zowongolera. Chofunikira, kuyankha kwa dopaminergic ku amphetamine mu otchova juga kunanenedweratu bwino ndi misinkhu ya D3 receptor (yoyesedwa muantiantia nigra), komanso kokhudzana ndi kutha kwa njuga, kulola kuti apange njira zamakanika zomwe zingathandize kufotokozera zopereka za DA ku PG. OZotsatira za ur ndizogwirizana ndi boma la hyperdopaminergic ku PG, ndikuthandizira malingaliro omwe amalimbikitsa kukhudzana kwa dopaminergic okhudzana ndi ma D3 okhudzana ndi njira zomwe zingathandizire kuti pathophysiology yokhudza zizolowezi zamakhalidwe.