MAFUNSO: Sindikukhulupirira kuti dopamine sichimakhudzidwa, monga momwe olemba akunenera. Choyamba adagwiritsa ntchito mdani wa D2. Nanga bwanji kuyambitsidwa kwa D1 komwe ndikofunikira kwambiri pakulimbikitsa? Komanso, tikudziwa kuti kulimbikitsidwa kumaphatikizapo PFC ndi amygdala glutamate zolowetsa zomwe zimagwira NaC. Kodi ndi glutamate wothandizira ma D1 receptors? Koma pano pali kusiyana kwakukulu pamalingaliro: pomwe zophonya pafupi ndizo "ZOPindulitsa kwambiri" kwa omwe ali ndi vuto la kutchova juga, zoperewera pafupi sizowona mphoto - kupambana ndiko. Dopamine amagwa pomwe zoyembekezera sizikukwaniritsidwa. Chiyembekezo pa nkhaniyi chikupambana.
April 13, 2016
Source:
Radboud University
Chidule cha nkhaniyi:
Ochita juga pazachidziwitso amakhala ndi ubongo wamphamvu pamachitidwe omwe amadziwika kuti akuphonya: kutaya zochitika zomwe zimayandikira pafupi ndikupambana. Akatswiri a Neuroscientist akuwonetsa izi mu fMRI kuwunika kwa otchovera njuga makumi awiri mphambu ziwiri komanso njira zambiri zowongolera.
Ochita juga pazachidziwitso amakhala ndi ubongo wamphamvu pamachitidwe omwe amadziwika kuti akuphonya: kutaya zochitika zomwe zimayandikira pafupi ndikupambana. Akatswiri a Neuroscientist a Donders Institute ku Radboud University akuwonetsa izi mu fMRI kuwunika kwa otchovera njuga okwana makumi awiri ndi ziwiri komanso maulamuliro ambiri athanzi. Buku la zasayansi Neuropsychopharmacology adafalitsa zotsatira zake mu nkhani yoyang'ana koyambirira sabata yatha.
Ngakhale kutayika kwakuthupi, zophonya zimayambitsa gawo lolingana ndi mphotho mkati mwa ubongo wathu: striatum. Pakafukufuku waposachedwa, katswiri wazam'madzi Guillaume Sescousse ndi mnzake akuwonetsa kuti ntchitoyi imakulitsidwa mwa otchovera njuga. Poyerekeza ndi zowongolera zathanzi, otchova njuga amawonetsa zochitika zambiri muzochitika pambuyo pa chochitika chosowa kwambiri, kuposa zochitika zonse. Ntchitoyi imaganiziridwa kuti imalimbikitsa mchitidwe wa kutchova juga, zomwe zikuwoneka kuti zimalimbikitsa kunyengerera kwa masewera pamasewera.
Kuti apeze zotsatirazi, Sescousse anayerekezera kuwunika kwa fMRI kwa otchovera njuga komanso achikulire athanzi pomwe anali kusewera masewera olowetsa. 'Tapangitsa kuti masewera athu otchova juga akhale ngati amoyo momwe angathere pokonzanso zowoneka, ndikuwonjezera mawu ena ndikusintha liwiro lamagudumu poyerekeza ndi am'mbuyomu. M'masewera athu, mwayi wophonya pang'ono unali 33%, poyerekeza ndi 17% yopambana ndipo 50% yaphonya kwathunthu. '
Kuphunzira mwakuya
Otchova juga ali ndi chinyengo champhamvu pakuwongolera ndipo amakhulupirira mwayi kuposa ena akatchova juga. 'Zinali zovuta kupeza maphunziro a kuyesaku', malinga ndi Sescousse. Kukula kwa kutchova juga kwamatenda ndikotsika ku Netherlands, ndipo kafukufuku wathu anali wolimba kwambiri. Anthu amayenera kubwerera ku Donders Institute katatu, ndipo samatha kukhala ndi zovuta zina, matenda kapena mankhwala osokoneza bongo. '
Kodi chikuchitika ndi chiyani m'malingaliro a wotchova juga akakumana ndi chochitika chomwe sichingachitike? Sescousse: 'Nthawi zonse zochitika zaposachedwa zikusonyeza kuti mukuphunzira: nthawi ino simunamvetsetsebe, koma pitirizani kuyeseza ndipo mudzatero. Zophonya pafupi zimalimbitsa machitidwe anu, zomwe zimachitika poyambitsa zochitika m'magawo okhudzana ndi mphotho monga striatum. Izi zimachitikanso kutchova juga. Koma makina olowetsa zinthu amakhala osasintha, mosiyana ndi moyo watsiku ndi tsiku, zomwe zimawapangitsa kukhala chovuta kwambiri kuubongo wathu. Ndicho chifukwa chake kuphonya kumeneku kumatha kupanga chinyengo pakuwongolera. '
Ndinadabwa
Kafukufuku wazinyama awonetsa kuti mayankho amachitidwe pazochitika zaposachedwa zimasinthidwa ndi dopamine, koma mphamvu ya dopaminergic inali isanayesedwe mwa anthu. Chifukwa chake, maphunziro onse adachita kuyesaku kawiri: nthawi imodzi atalandira blocker ya dopamine, ndipo nthawi ina atalandira malowa. Chodabwitsa ndichakuti, mayankho aubongo ku zochitika zaposachedwa sanatengeke ndi izi. 'Kwa ine, uku ndikutsimikizira kwina kovuta kwa malongosoledwe omwe tikugwira ntchito', Sescousse akufotokoza.
Mutu wa Nkhani:
Positi pamwambapa adalembedwanso kuchokera zipangizo operekedwa ndi Radboud University. Zindikirani: Zipangizo zingasinthidwe kuti zikhale zokhutira ndi kutalika.
Journal Ndemanga:
- Guillaume Sescousse, Lieneke K Janssen, Mahur M Hashemi, Monique HM Timmer, Dirk EM Geurts, Niels P ter Huurne, Luke Clark, Roshan Cools. Kuyankha Kwakukulu Kakuyankha ku Zotsatira Zapafupi Pamsika Pathological Gambler. Neuropsychopharmacology, 2016; DoI: 10.1038 / npp.2016.43
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