Br J Psychiatry. 2015 Jun 4. pii: bjp.bp.114.152223.
Verdejo-Garcia A1, Clark L1, Verdejo-Román J1, Albein-Urios N1, Martinez-Gonzalez JM1, Gutierrez B1, Soriano-Mas C1.
Kudalirika
Background
Anthu omwe ali ndi mankhwala osokoneza bongo a cocaine komanso a juga amawonetsa kulephera kosinthika komwe kungayambitse kupitilizabe kuchita zinthu zovulaza.
Zolinga
Tinafufuza magawo a neural magawo obisika a ogwiritsira ntchito cocaine v. Ogwiritsira ntchito zida zam'mimbamo, tikufuna kuthana ndi machitidwe wamba v. genotyped ku DRD18 / ANKK Taq18A polymorphism.
Results
Ogwiritsa ntchito Cocaine ndi otchovera juga wazitsulo adawonetsa kuchepetsedwa kwa ma polasi a prerolal preparal cortex (PFC) posinthira. Ogwiritsa ntchito Cocaine adawonetseranso kuchuluka kwa kubwezeretsa kwa dorsomedial PFC (dmPFC) pokhudzana ndi kutchova njuga panthawi ya kupirira, ndipo adachepetsa kutsegulira kwa dorsolateral PFC pokhudzana ndi otchova njuga komanso kuwongolera poyenda. Zotsatira zoyambirira zamtunduwu zidawonetsa kuti ogwiritsa ntchito mankhwala a cocaine omwe ali ndi DRD2 / ANKK Taq1A1 + genotype atha kukhala ndi zotsitsika zapadera pazisonyezo zokhudzana ndi kusintha kwa mpweya wa PFC.
Mawuwo
Kuchepetsa mphamvu zamagetsi ku PFC posuntha kumatha kukhala chizindikiritso chodziwika bwino m'guga ndi chizolowezi cha cocaine. Zowonjezera zokhudzana ndi cocaine zimayenderana ndi njira yayitali yokhudzana ndi kukomoka kwa ntchito, zomwe zimawonetsedwa ndi zovuta mu dorsolateral ndi dmPFC.
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