Neurosci Lett. 2019 Jun 11: 134328. doi: 10.1016 / j.neulet.2019.134328.
Bozorgmehr A1, Alizadeh F2, Sadeghi B3, Shahbazi A4, Ofogh SN4, Joghataei MT5, Razian S6, Heydari F7, Ghadirivasfi M8.
Kudalirika
Dongosolo la oxytocinergic limakopa chidwi chazomwe zimapangitsa kuti anthu azikhala ndi chidwi ndi maphunziro. Poganizira tag-nucleotide polymorphism (SNP) yomwe imapezeka pofufuza mtundu wina wa haplotype mumtundu wa oxytocin receptor (OXTR), tidasanthula momwe oxytocin imagwirira ntchito popanga zisankho zowopsa kudzera ku Iowa Gambling Task (IGT). Amuna achichepere athanzi amalandila intranasal oxytocin kapena placebo, ndipo IGT idachitidwa pomwe zambiri zaiwisi, kuchuluka kwa nthawi ndi nthawi yathunthu zidalembedwa, ndipo kuchuluka kwa zopindulitsa pazosankha zoyipa zinawerengedwa. Pogwiritsa ntchito PCR-pyrosequencing, 761 bp yolunjika mu jini la OXTR idakulitsidwa ndikutsatiridwa pambuyo pakuchotsa magazi athunthu a DNA. Kugwiritsa ntchito mtundu wa Haploview, haplotypes and linkage disequilibrium (LD) pakati pa ma 14 SNP onse m'chigawo chachilendo adatsimikiza kutengera mfundo za D 'ndi LOD, ndipo rs2254295 wokhala ndi LD yayikulu adawonetsedwa ngati chizindikiro SNP. GTT idawonetsedwa kuti imakhala ndimafupipafupi kwambiri pakati pa ma haplotypes omwe amapezeka. Gulu la Oxytocin ndi omwe ali nawo pa TT genotype adawonetsa kuchuluka kowonjezera, kuchuluka kwa zisankho ndi zisankho zabwino, pomwe nthawi yonseyo sinakhudzidwe modabwitsa. Izi zikutanthauza kuti oxytocin idachepetsa kwambiri chiopsezo popanga zisankho, ndipo omwe ali ndi genotype ya TT anali ndi zisankho zochepa msanga kapena zowopsa kuposa omwe ali ndi ma genotypes a CT ndi CC. rs2254295 imatha kusintha magwiridwe antchito kapena kufotokozera kwa jini la OXTR, kutanthauza kuti kutha kwa T kungakulitse kufotokozera kwa jini la OXTR poyerekeza ndi C yokhazikika. Tikuwonetsa kuti oxytocin imatha kuchepetsa kuwopsa kwa malingaliro ndi zotulukapo zake pakupanga chisankho chosatsimikizika.
MAFUNSO: Kupanga zisankho; Ntchito Yotchovera Juga; Ma polymorphisms a OXTR; Oxetocin; Machitidwe a polymerase
PMID: 31200092
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