Mov Disord. 2011 Feb 1; 26 (2): 225-33. doi: 10.1002 / mds.23480. Epub 2011 Jan 31.
Cilia R1, Cho SS, van Eimeren T, Marotta G, Siri C, Ko JH, Pellecchia G, Pezzoli G, Antoni A, Strafella AP.
Kudalirika
MALANGIZO:
Kutchova juga kwachidziwitso kumatha kuchitika mu matenda a Parkinson (PD) ngati vuto la mankhwala a dopaminergic. Kafukufuku wa Neuroimaging awonetsa kufalikira kwachilendo kwa dopamine m'dongosolo la mphotho, koma zosintha pamaneti a neural omwe amadziwika ndi omwe ali ndi PD omwe ali ndi vuto la kutchova juga sanayambe anafufuzidwapo.
ZITSANZO:
Odwala makumi atatu a PD (15 yokhala ndi juga yogwira ndi zowongolera za 15, mankhwala opangira mankhwala) ndi 15 maphunziro athanzi adatsitsidwa ndi ubongo wa bongo limodzi. Kuopsa kwa kutchova juga kunayesedwa pogwiritsa ntchito South Oaks Gcane Scale. Kusanthula kwa ndalama kunagwiritsidwa ntchito kuzindikira madera aubongo omwe ntchito zake zimagwirizanitsidwa ndi kuuma kwa njuga. Madera amenewa adagwiritsidwa ntchito ngati chidwi chambiri kuti athe kudziwa malo olumikizana pogwiritsa ntchito nzeru za pang'onopang'ono. Njira ya momwe adafotokozera idafotokozedwa pogwiritsa ntchito njira yolumikizira yolumikizana mu dongosolo la Structural Equation Modeling.
ZOKHUDZA:
Kuchepa kwa njuga mu PD kunalumikizidwa ndi kukanika kwa maukonde a ubongo ophatikizidwa pakupanga zisankho, kukonza zoopsa, ndi kuyimitsa poyankha, kuphatikiza polondera presetal cortex, anterior (ACC) ndi posterior cingate cortex, medial pre mbeleal cortex, insula ndi striatum. PD otchova juga adawonetsera kulumikizana pakati pa ACC ndi striatum, pomwe kulumikizanaku kunali kolimba kwambiri m'magulu onse olamulirawo.
ZOKAMBIRANA:
Kulumikizidwa kwa ACC kumatha kuyipitsa kusuntha kwa zotsatira zoyipa, mwina ndikufotokozera chifukwa chake otchova juga a PD amapitiliza kuchita zinthu zomwe zitha kukhala pachiwopsezo ngakhale atadzivulaza.
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