Chizoloŵezi. 2013 Meyi; 108 (5): 953-63. doi: 10.1111 / kuwonjezera.12066. Epub 2013 Jan 3.
Boileau I, Payer D, Chugani B, Lobo D, Behzadi A, Rusjan PM, Houle S, Wilson AA, Warsh J, Kish SJ, Zack M.
gwero
Gulu Lofufuzira Lamagetsi, Center for Addiction and Mental Health, Toronto, ON, Canada. [imelo ndiotetezedwa]
Kudalirika
ZOYENERA:
Kutchova njuga kwa matenda a m'magazi (PG) imagawana magawo a diagnostic omwe ali ndi vuto la kugwiritsa ntchito mankhwala osokoneza bongo (SUD), koma magwiridwe amomwe amayambira PG samamveka bwino. Chifukwa dopamine (DA), neurotransmitter yokhazikika mu mphotho ndi kulimbitsa, mwina ikukhudzidwa, tidagwiritsa ntchito positron emission tomography (PET) kuyesa ngati PG imagwirizanitsidwa ndi zovuta mu D2 ndi D3 receptor level, monga momwe anawonera SUD.
DONGO:
Kafukufuku wowongolera poyerekeza PG ndi maphunziro owongolera (HC).
SETTING:
Malo ophunzirira zaumaphunziro.
ACHINYAMATA:
Amuna khumi ndi atatu omwe safunafuna chithandizo amakumana ndi njira za DSM-IV za PG, ndipo 12 ikufanana ndi HC (11 yemwe anamaliza PET).
MALANGIZO:
Zolemba ziwiri za PET (chimodzi chomwe chili ndi D3 receptor chimakonda agonist [11C] - (+) - propyl-hexahydro-naphtho-oxazin (PHNO) ndi chinacho ndi [11C] raclopride) kuyesa kupezeka kwa D (2 / 3) DA receptor, ndi zoyeserera (kudzifunsa mafunso komanso masewera olowetsa makina) kuyesa zotsatira zamaubwenzi ndi maubale pa njira za PET.
ZOKUTHANDIZA:
Kumanga ma radiotracers onse sikunali kosiyana pakati pamagulu a striatum kapena substantia nigra (SN) (onse P> 0.1). Pakati pa PG, [11C] - (+) - PHNO yomanga mu SN, pomwe chizindikirocho chimachitika makamaka ndi ma D3 receptors, olumikizidwa ndi kutchova juga mwamphamvu (r = 0.57, P = 0.04) ndi kusakhazikika (r = 0.65, P = 0.03) . Ku HC, [11C] raclopride yomanga mu dorsal striatum yolumikizidwa molingana ndi zovuta zina za kutchova jugag (r = -0.70, P = 0.03) komanso kunyinyirika (r = -0.70, P = 0.03).
MAFUNSO:
Mosiyana ndi vuto la kugwiritsa ntchito mankhwala osokoneza bongo, zikuwoneka kuti palibe kusiyana kwakukulu pamlingo wa D2 / D3 pakati pa maphunziro athanzi ndi otchova njuga, kuwonetsa kuti kupezeka kwa receptor kochepa sikungakhale gawo lofunikira pakulipira. Komabe, maubwenzi apakati pa [11C] - (+) - PHNO yomangiriza ndi kutchova njuga mwamphamvu / kukakamiza kukusonyeza kuti kuphatikiza kwa D3 receptor kumakhalidwe oyenera / okakamiza.
© 2012 Alembi, Zowonjezera © 2012 Society for the Study of Addiction.
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