Ntchito ya hypothalamic-pituitary-adrenal axis kwa odwala omwe ali ndi vuto lakutchova njuga ndi matenda a intaneti (2014)

Zosintha pobisalira ya mahomoni opsinjika mkati mwa axoth ya hypothalamic-pituitary-adrenal (HPA) zapezeka mobwerezabwereza pamavuto okhudzana ndi mankhwala osokoneza bongo. Adanenanso kuti glucocorticoids imathandizira kukulitsa ndi kukonza mavuto obwera chifukwa chogwiritsa ntchito zinthu mothandizidwa ndi mayankho amachitidwe pazinthu zomwe zimagwiritsidwa ntchito mwankhanza. Cholinga cha kafukufukuyu ndikuwunika ntchito za axPA za HPA kwa odwala omwe ali ndi vuto losagwirizana ndi zinthu zina, mwachitsanzo, njuga ya pathological komanso vuto logwiritsa ntchito intaneti.

Tidayesa kuchuluka kwa plasma ya Copeptin, chizindikiro cha vasopressin surrogate, adrenocorticotropic hormone (ACTH) ndi cortisol mwa odwala amuna omwe ali ndi juga ya pathological (n = 14), kusokonezeka kwa ogwiritsa ntchito pa intaneti (n = 11) ndikufananiza kuwongolera koyenera kwa njuga ya pathological (n = 13 ) ndi vuto la kugwiritsa ntchito intaneti (n = 10).

Milingo ya plasma ya Copeptin, ACTH ndi cortisol mwa odwala omwe ali ndi juga ya pathological kapena vuto la kugwiritsa ntchito intaneti sizinasiyane pakati pamagulu.

Komabe, milingo ya cortisol plasma yolumikizana molakwika ndi kuopsa kwa kutchova juga kwazomwe zimayesedwa ndi PG-YBOCS. T

Pamodzi ndi zomwe tapeza zikuwonjezera kuchuluka kwa ma seramu omwe amachokera muubongo waubongo wopezeka muubongo koma osagwiritsa ntchito intaneti, zotsatirazi zikuonetsa kuti pathophysiology ya juga yamatenda amagawana zina mwazovuta zokhudzana ndi mankhwala osokoneza bongo omwe ali ndi vuto la neuroendocrinological, pomwe kufanana komwe sikunawoneke mu vuto la kugwiritsa ntchito intaneti.