MAFUNSO: Phunziro limapezekanso m'munsimu a D2 receptors mu dera la mphoto (striatum), lomwe likugwirizana ndi kuchuluka kwa ntchito. Anapezanso kuti magulu a dopamine receptors ogwirizana ndi hypofronatlity.
Eur J Nucl Med Mol Imaging. 2014 Jul;41(7):1388-97. doi: 10.1007/s00259-014-2708-8.
Zotsatira M1, Chen Q, Zhang Y, Du F, Hou H, Chao F, Zhang H.
Kudalirika
MALANGIZO:
Matenda a masewera a intaneti ndi vuto lalikulu padziko lonse lapansi, zomwe zimachititsa kuti anthu azivutika kwambiri pankhani za maphunziro, zachikhalidwe, ndi ntchito. Komabe, njira yokhayokha ya maseŵero a masewera a intaneti imakhala yosadziwika. Cholinga cha phunziroli ndikufufuza ubongo wa dopamine D2 (D2) / Serotonin 2A (5-HT2A) ndi ntchito ndi shuga ya m'magazi m'maganizo omwewo ndi njira ya positron emission tomography (PET), ndipo fufuzani ngati mgwirizano ulipo pakati pa receptor D2 komanso shuga wa shuga.
ZITSANZO:
Amuna khumi ndi awiri omwe ali ndi mankhwala osokoneza bongo omwe amakumana ndi zovuta zogwiritsira ntchito masewera a masewera a intaneti ndi ma 14 omwe anagwirizana nawo anaphunzitsidwa ndi PET ndi (11) CN-methylspiperone ((11) C-NMSP) kuti aone kupezeka kwa D2 / 5-HT2A receptors ndi ( 18) F-fluoro-D-shuga ((18) F-FDG) kuyesa ubongo wa m'madera m'madera a m'deralo, chizindikiro cha ubongo. (11) C-NMSP ndi (18) D-imaging PET yosungira deta inapezedwa mwa anthu omwewo pansi pazigawo zonse zozizira ndi intaneti.
ZOKHUDZA:
Pa masewera a masewera a intaneti, kuchepa kwakukulu kwa shuga m'magazi kunkaonekera m'makonzedwe apakompyuta, amitundu, ndi ziwalo. Kusokonezeka kwa ma receptors a D2 kunawonetsedwa mu striatum, ndipo kunagwirizanitsidwa ndi zaka zambiri. Mpata wotsika wa receptors wa D2 mu striatum unali wogwirizana kwambiri ndi kuchepa kwa shuga m'magazi mu orbitofrontal cortex.
MAFUNSO:
Kwa nthawi yoyamba, timalengeza umboni wakuti mlingo wa D2 receptor umagwirizanitsidwa kwambiri ndi kagayidwe ka shuga m'magazi omwewo ndi vuto la masewera a intaneti, zomwe zimasonyeza kuti kudetsedwa kwa D2 / 5-HT2A yokhala ndi mpata wa orbitofrontal cortex kungapangitse njira yowonongeka zolamulila ndi chizoloŵezi choyendetsa masewera a masewera a intaneti.
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