Dopamine amachititsa kuti pakhale ntchito zopindulitsa panthawi yoganizira za kugonana kwapadera (2012)

Neuropsychopharmacology. 2012 Jun;37(7):1729-37. doi: 10.1038/npp.2012.19.
 

gwero

Leiden Institute for Ubongo ndi Kuzindikiridwa-LIBC, University of Leiden, Leiden, Netherlands. [imelo ndiotetezedwa]

Kudalirika

Mankhwala a Dopaminergic amachititsa kuti anthu azichita zinthu zolimbitsa thupi, ndipo amayamba kuchita zinthu mopupuluma, monga chiwerewere.

Kafukufuku wakale asonyeza kuti chidziwitso chopanda chidziwitso cha kugonana zoyambitsa zimayambitsa madera aubongo omwe amadziwika kuti ndi gawo la 'mphotho'. Mu phunziro ili, izo zinaganiziridwa kuti dopamine amachititsa kuti ntchitoyi ikhale yovuta kwambiri, monga nucleus accumbens, panthawi yomwe kugonana zolimbikitsai.

Amuna achikulire aang'ono (n = 53) anapatsidwa magawo awiri magulu awiri oyesera kapena gulu lolamulira, ndipo anapatsidwa dopamine wotsutsa (haloperidol), a dopamine agonist (levodopa), kapena placebo. Kugwiritsa ntchito ubongo kunayesedwa pa ntchito yambuyo-masking nayo mwafotokozedwa mwachidule kugonana zosangalatsa.

Zotsatira zinawonetsa kuti levodopa kwambiri ikuthandizira kuchitidwa mu nucleus accumbens ndi dorsal anterior cingulate pamene subliminal kugonana Zisonyezero zinawonetsedwa, pamene haloperidol imachepetsa zochitika m'madera amenewo. Dopamine potero kumathandizira kuyambitsa madera omwe akuganiza kuti akuwongolera 'kufuna' poyankha zomwe zingakhale zopindulitsa kugonana zovuta zomwe sizikudziwika bwino. Kuyambira koyambira kwa mphotho kungathe kufotokozera kukopa kwa mphoto kwa anthu omwe ali ndi khalidwe lofunafuna mphoto monga chiwerewere ndi odwala omwe amalandira mankhwala a dopaminergic.