Psychoneuroendocrinology. 2015 Nov; 61: 53. onetsani: 10.1016 / j.psyneuen.2015.07.534. Epub 2015 Aug 8.
Chatzittofis A1, Arver S1, Öberg K1, Hallberg J1, Nordström P1, Jokinen J.
Mfundo
- Amuna omwe ali ndi vuto la hypersexual anali ndi chiwerengero cha DST chosagonjetsa kusiyana ndi machitidwe.
- Amuna omwe ali ndi vuto la hypersexual anali ndi maulendo apamwamba a DST-ACTH poyerekeza ndi machitidwe.
Kudalirika
Matenda opatsirana pogonana akuphatikizapo matenda okhudzana ndi chilakolako chogonana, chiwerewere, kukhudzidwa ndi kugonana komanso kukhumudwa kunanenedwa ngati matenda a DSM-5. Komabe, zochepa zimadziwika za matenda a neurobiology kumbuyo kwa matendawa. Kusokoneza kwa hypothalamic pituitary adrenal (HPA) axis kwawonetsedwa mu matenda a maganizo koma sanafufuzidwe ndi matenda a hypersexual. Cholinga cha phunziroli chinali kufufuza ntchito za ma HPA zokhudzana ndi matenda a hypersexual.
Phunziroli limaphatikizapo odwala a 67 omwe ali ndi vuto la hypersexual ndi 39 wathanzi amuna odzipereka. Ma basal m'mawonekedwe a plasma a cortisol ndi ACTH anayesedwa ndi ochepa mlingo (0.5 mg) dexamethasone kuponderezedwa kuyesedwa kwa cortisol ndi ACTH kuyeza post dexamethasone administration. Maonekedwe osagonjetsedwa amatanthauzidwa ndi DST-cortisol levels ≥138 nmol / l. Kugonana kwapakati pafupipafupi (SCS), matenda osokoneza bongo (Hypersexual disorder) (HD: CAS), Montgomery-Åsberg Kusokonezeka Maganizo-kudziwerengera (MADRS-S) ndi kufunsa mafunso osokoneza bongo (CTQ), anagwiritsidwa ntchito poyesa khalidwe lachiwerewere, kupsinjika maganizo komanso mavuto oyambirira a moyo.
Odwala omwe anali ndi matenda okhudzana ndi kugonana ndi abambo ambiri anali a DST omwe sanali a suppressors ndipo anali oposa DST-ACTH poyerekezera ndi odzipereka odzipereka. Odwalawo anafotokoza kuti ziwopsezo zambiri zaunyamata ndi zizindikiro za kuvutika maganizo zikuyerekeza poyerekeza ndi odzipereka odzipereka. Zolemba za CTQ zasonyeza kusemphana kwakukulu ndi DST-ACTH pamene SCS ndi HD: CAS ziwerengero zasonyeza kusagwirizana kolakwika ndi cortisol yoyambira kwa odwala. Matenda a hypersexual anagwirizanitsidwa kwambiri ndi DST osagonjetsa komanso apamwamba kwambiri a plasma DST-ACTH ngakhale atasinthidwa chifukwa cha kusokonezeka kwa ana.
Zotsatirazi zikusonyeza kuti matenda a HPA akudwalitsa pakati pa odwala amuna omwe ali ndi vuto la hypersexual.
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