Mutu wa zolaula (2017)

Mutu womwe umagwirizanitsidwa ndi zochitika zogonana (HSA) ndi gulu la masoka okhudzana ndi kugonana. Kugonana ndiye kutsogoleredwa pakugonana [1]. Mpaka pano, pali munthu m'modzi yekha yemwe amadziwika kuti amadwala mutu chifukwa cha zolaula [2]. Apa, timanena za wodwala wina yemwe wapeza zolemba ziwiri zodetsa nkhawa zomwe zimapangitsa kuti azimva ululu wokhudzana ndi kugonana kachikachiyama kukomoka.

Mnyamata wina wazaka 40 adalongosola kupwetekedwa mtima komanso kupweteka mutu, makamaka pa vertex, khosi komanso akachisi awiri, kwa chaka chimodzi. Ululu unayamba mkati mwa 1 min pambuyo poonera zolaula pa intaneti ndipo kukula kwake kudakulirakulira pang'onopang'ono. Ululu udatha pokhapokha wodwalayo atasiya kuonera. Wodwala adakana chilichonse aura, Chizindikiro chogwirizana, mawonekedwe a autonomic kapena kukweza kwa magazi panthawi ya ululu. Komabe, zogonana kapena cholinga chokomera kugonana (SA), monga kutentha nkhope, palpitation, kupumira msanga, khosi louma komanso / kapena kukhazikika kwa penile, kumayambiriro kwa zowawa. Ululu wolozera unangoyambitsidwa ndi zolaula, koma osati makanema kapena zithunzi zomwe sizili ndi zolaula kapena zandale, kukumbukira kukumbukira zochitika zolaula, maliseche okha / amisala okha popanda zolaula, thupi lamaliseche lagonana, kumva kugonana kumamveka kapena kugonana kwa mawu kuyitanitsa, kapena kuchita zachiwerewere. Ponena za zomwe zili muvidiyo yolakwika, kugonana amuna kapena akazi okhaokha ndi komwe kumalimbikitsa kwambiri makamaka ndikuyandikira. Kukula kwake kunali kocheperako pakumagonana amuna ndi akazi, lesibiyani mchitidwe wogonana ndi wothandizira. Kugonana amuna kapena akazi okhaokha sikunamupweteketse. Kupwetekako kunali kwamphamvu kwa ochita masewera achichepere kuposa achikulire popanda kusiyana fuko kapena poganiza zotenga nawo mbali.

Kukula kwakanthawi kwa HSA akuti ndi 1%. Posachedwa, Anand & Dhikav [2] adatero wodwala woyamba wodziwika bwino wokhudza zolaula. Amayerekezera ululu womwe udayamba pikosakina mphamvu ndi minofu contraction, zochokera kwambiri kufala kwa migraine mu HSA ndi preorgasmic kuukira odwala awo. Komabe, odwala awo ndi athu sakumva mutu kapena kupweteka kwa mutu wam'mimba komanso ululu wokhudzana ndi preorgasmic siwosiyana ndi kufooka kwa minofu. Muwodwala athu, mwapeza zinthu ziwiri zapadera zokhudzana ndi mutu wapaderawu, womwe ndi, US activation isanachitike komanso vasoconstriction pa ululu. Zotsatirazi zikuwonetsa kuti mutu wama zolaula ndi ululu wapadera wogonana womwe umakhudzana ndi ma network a SA, monga hypothalamus zomwe zimayang'anira Autonomic reaction.

In wodwala index, kupweteka kwakukulu kumachitika ndi kukula kwake ndikufanana ndi kukula kwa SA, ndikuwonetsa kutsegukira kwachidziwikire mwina woyang'anira pakhomo module kwa zolaula zam'mutu. Nthawi zambiri, kukula kwa kutsegulira zimatengera zinthu zingapo, monga jenda, zaka, mulingo wa mahomoni ogonana, malingaliro azogonana, ndi mawonekedwe amakopedwe ogonana. Ntchito inayake yapamwamba kwambiri yokhudzana ndi kugonana amuna kapena akazi okhaokha, kuyerekezera kopanga masewera olimbitsa thupi ndi azimayi ochita masewera olimbitsa thupi pamalingaliro a odwala amathandizira kuti mtima wokonda zogonana ndi zomwe amakonda [3] ndi kuyerekezera kuti atengepo mbali [3] amathandizanso kapena kukonza mphamvu ku SA. Chosangalatsa ndichakuti zowawa zimangotanthauza ku SA kokha chifukwa cha zolaula koma osati machitidwe ena ogona enieni ogona. Izi zikuwonetsa njira ina yosasinthira komanso njira zopweteka zomwe zilipo pakati pa mutu wolaula ndi HSA ina ngakhale kuti pali zolimbikitsa zofananira.

Kutulutsa magazi kozungulira kwamatumbo koyenda mozungulira mkati mwa ululu kumayesa SA-mediated kachikachiyama dysregulation kuti ikhale yothekera yopweteka mu index wodwala. Njira yowonjezerayi ikugwirizana ndi zokopa zowoneka kapena zowopsa, zolimbikitsa zosawoneka bwino mu migraineurs kapena kumva kupweteka. M'malo mwake, imagwirizana ndi focal vasoconstriction, monga chosinthika ubongo vasoconstriction syndrome. M'malo mwake, dysregulatory vasoconstriction nthawi zina imathandizira kupweteka kwa mutu wa preorgasmic kwa odwala a HSA [4] zofanana ndi zathu. Kutengedwa palimodzi, kupweteka kwa mutu wa zolaula kumapangidwira kukonzanso kwakanema kwa SA-mediated kaamba ka kubadwa kwa visuoneural kusasinthika mpaka kukopa kolimbikitsa. Komabe, zitha kukhudzidwanso ndi zinthu zina, monga kupsinjika ndi nkhawa, manyazi, kulakwa kapena malingaliro ena olakwika, makamaka mdera lachipembedzo.

Wodwala wathu adalabadira kuti atiteteze indomethacin monga taonera ma syndromes ena amkati am'mutu [5]. Indomethacin nthawi zina amapindula mtundu wa preorgasmic ndi orgasmic HSA yofanana ndi yathu. Makina ake a pharmacological amaikidwa kuti ateteze kutupa ndi chopinga chopikisana pa cyclo-oxygenase 1 ndi 2, phospholipase A2, kapena gluthation S-transferase. Wodwala wopweteketsa mutu wam'mbuyomu, kupweteka kunachepetsa ibuprofen ndi paracetamol kasakanizidwe [2]. Chifukwa chake, prophylaxis yokhala ndi nthawi yochepa ya indomethacin kapena ibuprofen imalangizidwa kuti ichite zolaula pamutu.

Mutu wamatsenga wamtambo ndi vuto losiyanitsa mutu lokhudza kugwiritsa ntchito zolaula ndipo ndi losiyana ndi ena a HSA. Akufunsidwa kuti atuluke chifukwa chosakhudzana ndi SA-Mediated kachikachiyama kukomoka. Mankhwala othandizira ndi indomethacin wopindula. Mutu wamaliseche uyenera kuchenjezedwa ngati vasomotor Kusintha kulipo. Zitha kuchepetsedwa ponseponse wakupha wowawa Kugwiritsa ntchito mopitirira muyeso kumatha kubisa zomwe zikuchitika zenizeni zenizeni padziko lapansi.

Olemba, pamenepa, akunenetsa kuti palibe vuto lililonse pankhani iyi.