Behav Brain Res. 2013 Nov 1;256:64-71. doi: 10.1016/j.bbr.2013.07.056.
Garduño-Gutiérrez R , León-Olea M , Rodríguez-Manzo G.
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Departamento de Farmacobiología, Cinvestav Sede Sur, Calzada de los Tenorios 235, Col. Granjas Coapa, Delegación Tlalpan, CP 14330, México DF, Mexico; Departamento de Neuromorfología Funcional, Dirección de Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Av. México-Xochimilco 101, Col. San Lorenzo Huipulco, CP 14370, México, DF, Mexico.
Kudalirika
Amphongo omwe amaloledwa kukwaniritsa mpaka atatha kugonana amasonyeza chizoloŵezi chogonana chokhalitsa (pafupi ndi 72h) chomwe chingasinthidwe ndi dongosolo la opioid receptor antagonist administration. Kuphatikizako kumayambitsa masolimbic dopaminergic system (MLS) ndipo imalimbikitsa kumasulidwa kosatha kwa opioid. Kuonjezera apo, opioids osagwiritsidwa ntchito, omwe amachititsa mchitidwe wa ventral tegmental (VTA), amayendetsa ntchito ya MLS.
Tinaganiza kuti ma opioid achilengedwe amatenga nawo mbali mu vuto la kutopa pogonana pogwiritsa ntchito ma opioid receptors a VTA ndipo chifukwa chake, kusinthidwa kwake ndi ma opioid antagonists kumatha kuchitika pama receptor amenewo.
Mu phunziro lino tinatsimikiza zotsatira za intra-VTA kulowetsedwa kwa mitundu yosiyanasiyana ya osagwirizana ndi opioid receptor antagonist naltrexone (0.1-1.0μg / rat) pa khalidwe lokhazikitsidwa kale la kugonana pofuna kupewa ziphuphu zamphongo zofooka. Pofuna kudziwa kuti pali njira zowonjezereka za VTA δ-opioid receptors mu vuto la naltrexone losinthira kugonana, zotsatira za mitundu yosiyanasiyana ya anti-opioid receptor antagonist, naltrindole (0.03-1.0μg / rat) inayesedwa.
Zotsatira zake zasonyeza kuti kubayidwa kwa naltrexone mkati mwa VTA kwa 0.3μg kunasintha njira yoletsa kugonana kwa makoswe otopa pogonana , zomwe zawonetsedwa ndi kuchuluka kwa ziweto zomwe zimatha kuwonetsa kutulutsa umuna kawiri motsatizana . Naltrindole yolowetsedwa mu Intra-VTA sinasinthe kutopa pogonana pa mlingo uliwonse. Zatsimikiziridwa kuti MLS ikukhudzidwa ndi kusintha kwa kutopa pogonana komwe kumachitika chifukwa cha naltrexone, ndipo kuti μ-, koma osati δ-opioid receptors imatenga nawo mbali pa izi . Kulowetsedwa kwa naltrexone mkati mwa VTA kwa makoswe aamuna otopa pogonana kunali ndi zotsatira zoletsa kugonana. Zotsatira zosiyana za naltrexone mkati mwa VTA pa machitidwe ogonana a makoswe aamuna omwe amawonetsa machitidwe ogonana a makoswe otopa pogonana zikukambidwa.
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