Kusanthula kwa meta kwa kafukufuku wokhudza zithunzi za ubongo kukuwonetsa kuti vuto la khalidwe logonana lokakamiza (CSBD) limagwirizana ndi kusiyana kwa ubongo komwe kumayesedwa.
Kudalirika
Background
Matenda okakamiza kugonana (CSBD) amakhudza zilakolako zogonana zosalamulirika komanso machitidwe omwe amayambitsa kuvutika maganizo kapena kulephera kugwira ntchito bwino. Ngakhale kuti amaikidwa m'gulu la matenda oletsa kukhudzidwa ndi zinthu zomwe zimayambitsa kuvutika maganizo kapena kusokonezeka kwa ntchito. Ngakhale kuti amaonedwa ngati matenda oletsa kukhudzidwa ndi zinthu zomwe zimayambitsa kusokonezeka kwa ubongo mu ICD-11, maziko ake a ubongo ndi kulephera kwa chidziwitso sikumveka bwino. Kupita patsogolo kwa mitundu yayikulu ya zilankhulo (LLMs) kumathandiza kusanthula mabuku ndi kupanga zithunzi zambiri za ubongo. Kafukufukuyu adagwiritsa ntchito njira ya LLM yogwiritsira ntchito meta-analysis yochokera ku coordinate ndi functional decoding kuti apange mapu a ubongo ndi kuzindikira kwa CSBD omwe amalumikiza kusintha kwa ubongo ndi kusokonezeka kwa chidziwitso.
Njira
Maphunziro okhudzana ndi kapangidwe kake ndi magwiridwe antchito a neuroimaging a CSBD adazindikirika kudzera mu kuyesa kwa semantic mu Neurosynth Compose. Ma Coordinates adachotsedwa ndikupangidwa pogwiritsa ntchito Multi-level Kernel Density Analysis (MKDA-χ 2 ), ndi kusanthula kwa magulu ang'onoang'ono komwe kudachitika malinga ndi mawonekedwe a kafukufuku. Mamapu a ubongo omwe adatsatira adalembedwa ntchito mu NeuroVault kuti adziwe magawo okhudzana ndi kuzindikira, malingaliro, chilimbikitso, ndi khalidwe.
Results
Kusanthula kwa meta kunawonetsa kusakhazikika kwa hippocampus yakumanzere, lower parietal lobule, precentral gyrus, putamen, ndi angular gyrus, komanso mu globus pallidus yakumanja ndi supramarginal gyrus. Kafukufuku wozikidwa pa ntchito makamaka adakhudza lower parietal lobule, hippocampus, ndi globus pallidus, pomwe maphunziro opumula adawonetsa kukhudzidwa kwa cerebellar. Mu zitsanzo zaku Europe, kusakhazikika kudawonekera mu globus pallidus, precentral gyrus, ndi hippocampus, pomwe zitsanzo zaku East Asia zidawonetsa kusintha mu lower parietal lobule ndi precuneus. Kuzindikira magwiridwe antchito kunagwirizanitsa machitidwe awa ndi kuchedwa kwa chilimbikitso, nkhawa, kuyanjana ndi anthu, komanso kuletsa kuyankha.
Kutsiliza
CSBD ikhoza kuwonetsa njira ziwiri zosokoneza zomwe zimaphatikizapo kuchititsa kuti striato-limbic reward-motivation circuitry igwire ntchito kwambiri komanso kulephera kulamulira kuchokera pansi kupita pansi mkati mwa netiweki ya frontoparietal, zomwe zimalimbikitsa machitidwe ogonana opitilira komanso okakamiza.