MAFUNSO: Kusangalala pogwiritsa ntchito makoswe kumakhala ndi vuto mu dopamine ndikupanga zomwe zimatchedwa malo okonda malo- omwe amakonda kucheza komwe adalandira mphotho yayikulu modabwitsa. Makoswe & anthu omwe ali ndi vuto losokoneza bongo amapeza zomwe amakonda. M'malo mwake, kubwerera kumalo omwe kale munkagwiritsa ntchito mankhwala osokoneza bongo ndizomwe zimayambitsa kuyambiranso.
Mu kafukufukuyu aerobic zolimbitsa thupi (mawilo othamanga) zinathetsa kangaude wa dopamine yemwe amayambitsidwa ndi Ecstasy, komanso malo omwe amakonda. Mwakutero chinathetsa malingaliro aliwonse a chidakwa. Zinatero popanda kusokoneza ma dopamine ndi ma dopamine receptors. Kumbukirani kuti zosokoneza bongo zonse zimagwirizana ndi njira zingapo zaubongo, makamaka kuwonetsa kusokoneza. Chifukwa chake olimbitsa thupi.
Behav Brain Res. 2008 Feb 11; 187 (1): 185-9. Epub 2007 Sep 16.
Chen HI, Kuo YM, Liao CH, Jen CJ, Huang AM, Cherng CG, Su SW, Yu L.
Dipatimenti ya Zanyama, National Cheng Kung University College of Medicine, Tainan 701, Taiwan, ROC.
Kudalirika
Ngakhale masewera olimbitsa thupi adadziwika kuti amayang'anira ubongo wa ubongo, momwe zimakhudzira mphotho ya psychostimulant ndi dongosolo la mesolimbic dopamine lidakhalabe likufufuzidwa. Psychostimulant, 3,4-methylenedioxymethamphetamine (MDMA), pakali pano ndi mankhwala osankhidwa padziko lonse lapansi. Tinaganiza zowunikira zotsatira zolimbitsa thupi kwa nthawi yayitali, zolimbitsa thupi pa hedonic mtengo wa MDMA mu mbewa zachimuna za C57BL / 6J.
MDMA yokhazikitsidwa ndi malo okonda malo (CPP) idagwiritsidwa ntchito ngati njira yowonetsera phindu la MDMA. Tinaona kuti mbewa zowongolera zonse zinaonetsa CPP yodalirika ya CPMA yokhala ndi protocol yathu. Chochititsa chidwi, kuwonetseratu kwa masewera olimbitsa thupi osokoneza bongo kumachepetsa mphamvu ya MDMA yotsatsira pambuyo pake. Makamaka, mbewa zomwe zimachita masewera olimbitsa thupi a 12-sabata yayitali sizinawonetse kuyandikira kwa chipinda chogwirizana ndi MDMA mu paradigm ya CPP.
Masabata 12 treadmill akuthamanga sanasinthe zotumphukira za MDMA 30min kutsatira jekeseni imodzi yokha ya MDMA (3mg / kg). Tidagwiritsanso ntchito njira ya micodialysis kuti tidziwe njira zomwe zimapangidwira mphotho ya MDMA yaulemu yopangidwa ndi 12-sabata yolimbitsa thupi. Tidapeza kuti MDMA-yolimbikitsidwa ya dopamine kumasulidwa mu ma nyukiliya ikuyimitsidwa mu mbewa zochitidwa, pomwe kukweza kwodziwikiratu kwa kutuluka kwa dopamine kumawonedwa mu mbewa zowongolera.
Pomaliza, pulogalamu ya masewera olimbitsa thupi ya 12-sabata sinasinthe kuchuluka kwa mapuloteni a ma dopamine receptors, ma vesicular kapena ma membrane oyendetsa m'derali. Timalingalira kuti ntchito yayitali, yolimbikira ndiyothandiza kuthana ndi phindu la MDMA mwina kudzera munthawi yake pobwezeretsa kutulutsidwa kwa dMA.
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